![]() ![]() ![]() In the general community trials involving 10,708 participants, the pooled RR was 0.97 (95% confidence interval (CI) 0.94 to 1.00). Twenty-nine trial comparisons involving 11,306 participants contributed to the meta-analysis on the risk ratio (RR) of developing a cold whilst taking vitamin C regularly over the study period. 'Duration' was the mean number of days of illness of cold episodes. ![]() We assessed 'incidence' of colds during regular supplementation as the proportion of participants experiencing one or more colds during the study period. Two review authors independently extracted data. We restricted our review to placebo-controlled trials. We excluded trials which used less than 0.2 g per day of vitamin C and trials without a placebo comparison. National Institutes of Health trials register and WHO ICTRP on 29 November 2012. We searched CENTRAL 2012, Issue 11, MEDLINE (1966 to November week 3, 2012), EMBASE (1990 to November 2012), CINAHL (January 2010 to November 2012), LILACS (January 2010 to November 2012) and Web of Science (January 2010 to November 2012). To find out whether vitamin C reduces the incidence, the duration or severity of the common cold when used either as a continuous regular supplementation every day or as a therapy at the onset of cold symptoms. Vitamin C (ascorbic acid) for preventing and treating the common cold has been a subject of controversy for 70 years. ![]()
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